Thursday, October 22, 2009

Resources on antidiabetic drugs

So here are some journal articles I found regarding the three different types of antidiabetic drugs. Basicially sulfonylurea works by increasing the insulin release from the pancreas while biguanides regulates the glucose production in the liver and thiazolidinediones help cells become more insulin sensitive. I will talk about all these in much more detail in the research paper and the diagrams.

Actually, after researching some more, I decided to just focus on biguanides.

Metabolic Effects of Metformin in Non-Insulin-Dependent Diabetes Mellitus - http://content.nejm.org/cgi/content/full/333/9/550

Re-evaluation of a biguanide, metformin: mechanism of action and tolerability
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WP9-4BRT5VY-11&_user=489256&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000022721&_version=1&_urlVersion=0&_userid=489256&md5=9e3c9b336b5fad0f7c74d43c947271af

Metformin
http://proxy.library.upenn.edu:2252/cgi/content/short/334/9/574

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism.
http://www.ncbi.nlm.nih.gov/pubmed/12145153

Metformin: a new treatment option for non-insulin-dependent diabetes mellitus
http://findarticles.com/p/articles/mi_m0689/is_n6_v42/ai_18448465/

Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus
this one isn't available online, but it says it's available through Penn's catalog, so I will go check it out soon.
http://elinks.library.upenn.edu/sfx_local?sid=google&auinit=CJ&aulast=Dunn&atitle=Metformin.+A+review+of+its+pharmacological+properties+and+therapeutic+use+in+non-insulin-dependent+diabetes+mellitus.&id=pmid:7601013

Cellular mechanism of action of metformin
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&doptcmdl=Abstract&term=0149-5992%20AND%201990%5BPublication%20Date%5D%20AND%2013%5BVolume%5D%20AND%20696%5BPage%20Number%5D

No comments:

Post a Comment